Rapid Toxicity Tests

first_imgThe methods used by the Regenerative Bioscience Center will expand the number of chemicals that can be tested each year, reducing process time, effort and cost while also minimizing animal use. “By better predicting whether chemicals have the potential to impact health and human development, these grants will not only advance the science necessary to improve chemical safety but protect the well-being and futures of children in this nation,” said Lek Kadeli of the EPA’s Office of Research and Development. “This is an opportunity to further foster interdisciplinary research that encompasses toxicology, neural development, stem cells and new imaging technology,” Stice said. Because of the damaging presence of these toxicants, early interruptions in brain development can lead to a broad range of lifelong problems. With one in six children in the U.S. diagnosed with a developmental or cognitive disorder, “it is more important than ever to understand the potential toxicity in the chemicals that we come in contact with every day,” Stice said. Multiyear testing methods have left the U.S. Environmental Protection Agency with a list of 80,000 household and industrial compounds that need to be assessed to determine potential health risks. Until now, determining the toxicity of each chemical could take almost two years. The UGA Regenerative Bioscience Center’s $799,938 share of the grant will allow researchers to modernize the current testing process using work they pioneered using undifferentiated cells. Stice presented the topic, “Human Neural Stem Cell Metabolomic, Cellular and Organ Level Adverse Outcome Pathway Relationships for Endocrine Active Compounds,” to 6,000-plus toxicologists from more than 50 countries on March 25 at the EPA Grants Kick-Off Meeting, part of the annual Society of Toxicology gathering in Phoenix, Ariz.center_img The funding for the Regenerative Bioscience Center’s study is provided by the EPA under grant No. R835551 on “Human Neural Stem Cell Metabolomic, Cellular and Organ Level Adverse Outcome Pathway Relationships for Endocrine Active Compounds.” For more information on the grant, see http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/10209/report/0. “This grant will span a wide range of disciplines to follow a toxin’s initial effects at the neural stem cells to how it affects people, potentially leading to uncovering environmental causes of autism. With EPA funding we can be a task force of a much-needed solution.” To help change the paradigm of how these chemicals are tested — and how rapidly the EPA receives results — the agency tapped researchers in the University of Georgia Regenerative Bioscience Center. The university is one of three institutions sharing a $3 million grant from the EPA to more quickly determine the physiological effects of environment chemicals on children and infants. The average American comes in contact with thousands of these chemicals each year. The biggest concern, though, is determining which of these compounds disrupt early fetal and infant brain development. “We hope to do a study in a dish that can be completed within a week so we’ll be able to speed up the process and make it less expensive and not have to use animals,” said center Director Steve Stice, a Georgia Research Alliance Eminent Scholar in Reproductive Physiology in the UGA College of Agricultural and Environmental Sciences.last_img read more

Fly Fish Haywood County, North Carolina

first_imgThere is nothing quite like the memory of the time you caught your very first fish.  Whether you were a child or just felt like a child at heart, there is something very special about the moment when you fought the flipping and flopping to eventually land your first fish.  You can re-live that same memory with a trip to the NC Smokies of Haywood to cast your line on the Mountain Heritage Trout Waters.The program was established by North Carolina in 2007 to encourage trout fishing as a heritage tourism offering and needless to say, it was a big hit! Every year, both novice and experienced anglers flock to the pristine rivers and streams of Haywood County to cast their lines.  The towns of Maggie Valley and Waynesville are the two access areas in Haywood County where you can fish on the Mountain Heritage Trout waters.Fishing 2Both residents and non-residents of North Carolina who want to fish the designated Mountain Heritage Trout Waters can purchase a 3-day license for only $5.00! Keep in mind the license is valid only for waters that have been designated as Mountain Heritage Trout Waters, but with multiple access points through Haywood County, you won’t have a problem finding the perfect fishing hole. This special 3-day license can be purchased online at www.ncwildlife.org or by telephone Monday – Friday, 8:00 AM – 5:00 PM at 888-248-6834. Don’t have a trusty rod and reel? No worries! Stop by the Haywood County Visitor Center at 1110 Soco Road and pick up a free tackle box filled with lures or flies and borrow either a fly rod or a spinner rod. It’s the perfect opportunity to brush up on your skills or share the joys of fishing our local streams and rivers with someone for the first time. If you’re not familiar with the access points of the Mountain Heritage Trout Waters, we’ve got you covered on that one as well.  Visit NC Smokies offers a free Mountain Heritage Trout Waters map that highlights the access points throughout Maggie Valley. On the map you’ll also find another unique trail – the Plott Dog Trail, which tells the story of the official state dog of North Carolina, the Plott Hound. These incredible dogs originated in Haywood County and have left their mark on the area’s history and heritage. The trail traces the history of the dog throughout Maggie Valley and includes some pretty incredible landmarks that are well worth the visit.76085_Trout Map001.pdf.pdfAnd don’t forget that Haywood’s five towns — Maggie Valley, Waynesville, Canton, Clyde and Lake Junaluska — are conveniently located within the county and serve as the perfect base camp to launch your adventures from. Make plans to stay the night in one of the five towns and enjoy local craft breweries, an eclectic culinary scene, live music venues, fun festivals, and much more. To plan your next excursion in Haywood County visit www.visitncsmokies.com. last_img read more

LIRR Adds 8 Trains for Jewish Holidays

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York The Long Island Rail Road is adding eight eastbound trains from Penn Station on Wednesday and Friday afternoon for commuters leaving work early for Rosh Hashanah and Yom Kippur.They include three trains each on the Port Jefferson and Babylon branches and one train each on the Port Washington and Far Rockaway lines.The Port Jeff trains leave at 2:08 p.m., 2:29 p.m. and 3:24 p.m. The Babylon trains leave at 2:32 p.m., 3 p.m. and 3:31 p.m. The Port Washington train leaves at 3:40 p.m. and the Far Rockaway train leaves at 3:48 p.m.For additional information, customers can consult the LIRR’s website or contact the LIRR’s Travel Information Center by calling 511.last_img

Wow. These Guys Are AMAZING Pole Dancers. Wait, What? (SFW) (Video)

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Here at The Buzz, we’ve had history with pole dancing. Often relegated to the underworld of scantily clad women who perform for ogling dollar bill rainmakers, I have shown how in some cases, this artform can be physically and artistically astounding.Then there’s my ex-girlfirend who I ran into when I was at… Um. Never mind.In any case, there is something to be said for scantily-clad acrobats, pouncing, swirling, ululating and sliding up and down a pole, in an impressive display of Olympian-like dexterity.Even if those scantily-clad pole performers are dudes.Wait. What?Yep. This shows another side to the pole-dancing phenomenon that had taken the rap world, and the suburban-mom-readers-of-50-Shades-of-Gray world, by storm.It’s an older video, so you may have seen it before, but if not, prepare to be amazed!(And fellas, it’s still worth the watch, but be prepared to cringe a little. OK. A lot.)And thanks to Eve for bringing this to my attention. Freak.last_img read more

Foundation grant helps spread “Financial Reality” to youth in Alaska

first_img 15SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr The Foundation is a huge believer in experiential learning, or learning by “doing”. One example of this is high school Reality Fairs, which is an interactive fair for high school students to help prepare them for their financial futures. Today, 26 states are offering students Reality Fair Programs – 14 of which can be tied directly to the Foundation.The Financial Reality Foundation (FRF) of Alaska recently utilized a grant from the Foundation to bring financial education to high school seniors via credit unions across the state of Alaska. Through their Get REAL Financial Reality Fair Program, they reached 2,663 students, which is 34% of all enrolled high school seniors in Alaska.FRF offers financial reality fairs for free to communities by way of the cooperation among Alaskan credit unions. The Alaska Credit Union League has been a major supporter in bringing financial literacy efforts state-wide by providing the Get REAL Financial Reality Fairs in their respective communities and membership areas. Seeing the enthusiasm from schools and collaboration from credit unions, Matanuska Valley FCU was inspired to create FRF in August 2014, as a non-profit foundation to provide consumers the opportunity to learn about finances in a fun, realistic and memorable way. continue reading »last_img read more

Rights of passage

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London residential portfolio drives Grosvenor profits up

first_imgTo access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week. Would you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletterslast_img

Tottenham respond to Juve’s Tanguy Ndombele-Aaron Ramsey swap deal proposal

first_imgTanguy Ndombele has failed to win the trust of Jose Mourinho while Aaron Ramsey is struggling to settle at Juventus (Picture: Getty)Tottenham have turned down the opportunity to sign Aaron Ramsey in a swap deal which would have seen Tanguy Ndombele move in the opposite direction.The Italian champions, according to the Daily Telegraph, expressed an interest in Spurs’ record signing who has struggled to win the confidence of Jose Mourinho.Despite a reported bust-up with Mauricio Pochettino’s successor following last month’s draw against Manchester United, where he was an unused substitute, the former Lyon star is still said to be part of Mourinho’s long-term plans. Ramsey, meanwhile, who joined Juventus on a free transfer from Arsenal last summer, has found his maiden season in Italy similarly hardgoing. AdvertisementAdvertisementADVERTISEMENTInjuries have stunted the Wales international’s progress, while he has also found it tough to adapt to the tactical demands of is new manager Maurizio Sarri. Mourinho’s thoughts after Spurs lose 3-1 to Sheff Utd, and that VAR callTo view this video please enable JavaScript, and consider upgrading to a web browser that supports HTML5 video Play VideoLoaded: 0%0:00Progress: 0%PlayMuteCurrent Time 0:00/Duration Time 10:19FullscreenMourinho’s thoughts after Spurs lose 3-1 to Sheff Utd, and that VAR callhttps://metro.co.uk/video/mourinhos-thoughts-spurs-lose-3-1-sheff-utd-var-call-2203580/This is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Earlier this week Juventus confirmed the signing of Arthurs Melo from Barcelona and are prepared to listen to offers for Ramsey, despite Miralem Pjanic’s departure to the Spanish giants. Tottenham, however, are said to have no interest in player who spent 12 years at north London rivals Arsenal and scored the winning goal in two FA Cup finals. More: Arsenal FCArsenal flop Denis Suarez delivers verdict on Thomas Partey and Lucas Torreira movesThomas Partey debut? Ian Wright picks his Arsenal starting XI vs Manchester CityArsene Wenger explains why Mikel Arteta is ‘lucky’ to be managing ArsenalNdombele, meanwhile, made his first appearance since Project Restart as a second half substitute in last night’s 3-1 defeat at Sheffield United which all but ended Tottenham’s hopes of Champions League qualification. ‘It’s very very difficult to dream of the Champions League and it will be a very, very difficult, tough fight with other clubs like Sheffield (United), Arsenal, Everton and lots of clubs that are going to fight for the Europa League spots,’ Mourinho conceded afterwards. Follow Metro Sport across our social channels, on Facebook, Twitter and Instagram.For more stories like this, check our sport page. Comment Advertisement Metro Sport ReporterFriday 3 Jul 2020 4:34 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link1.3kShares Tottenham respond to Juve’s Tanguy Ndombele-Aaron Ramsey swap deal proposal Advertisementlast_img read more

“Vibrant” selling market prompts duplex sale

first_imgThe galley-style kitchen. Indoor-outdoor living flows seamlessly.Since his tenants moved out, Mr Wolfe has “renovated it back to better than what it ever was before.”More from news02:37International architect Desmond Brooks selling luxury beach villa19 hours ago02:37Gold Coast property: Sovereign Islands mega mansion hits market with $16m price tag2 days agoHaving lived in the duplex himself before renting it out, Mr Wolfe said it had open-plan living areas and the entire top-level was a master retreat with views of the Broadwater and Surfers skyline. The kitchen is galley-style and a second living room has been wired, ready to be converted and used as a media room. The property has a 12.5 metre lap pool.“The top level also catches the sea breeze off the Broadwater, I don’t need to use the airconditioning much,” Mr Wolfe said.Set just back from Paradise Point Esplanade, the property is also central to shopping and transport.Mr Wolfe has listed his property due to timing and convenience.“Most of my work is in Sydney and Melbourne, albeit I can work out of Brisbane,” he said.“I think it’s a good time to sell, the Coast has come back and it’s quite vibrant.”center_img 1/17 Errol Ave, Paradise Point is set to go to auction next month.AFTER being a rental property for a while this Paradise Point home has undergone a “cosmetic renovation”, with the timber floors lacquered and the inside newly painted. The three-bedroom duplex, owned by David Wolfe, has a 12.5 metre swimming pool and an outdoor entertainment area.last_img read more

The suburbs where owner occupiers live

first_imgCore Logic has said 47 per cent of properties in Townsville are selling at a loss . Dean Dank, Principal at Explore Property TownsvilleRANGEWOOD has topped the list of Townsville suburbs with the most owner-occupiers.According to CoreLogic figures, only 5 per cent of households in the semi-rural suburb are renters. A total of 36.8 per cent own their home outright, 56.6 per cent are purchasers and the rest are classified as “other”.Explore Property Townsville principal Dean Dank said the suburb was popular with owner-occupiers because it was family-friendly and offered an idyllic lifestyle with larger blocks.He recently sold 55 Rangewood Drv in Rangewood to owner-occupiers, while the vendor had lived in the home for decades but had decided to downsize.The home was on the market for less than a month. Mr Dank said buyers were conscious of whether the area they were buying into had lots of renters.More from news01:21Buyer demand explodes in Townsville’s 2019 flood-affected suburbs12 Sep 202001:21‘Giant surge’ in new home sales lifts Townsville property market10 Sep 2020“People will ask if there is mainly renters or if it’s owner-occupiers, so we try to find that out as part of the listing,” he said.“I think Rangewood is so popular with owner-occupiers because of families that want space, whereas the new developments are building smaller and smaller blocks.“It is very family-orientated.”Mr Dank said a new wave of homeowners were starting to buy property in Rangewood.“There is a bit of a changing of the guard happening in Rangewood with people in their 60s and 70s downsizing,” he said.“You can also have a bore there and it’s not as far out of town as Rupertswood.”All the suburbs in the top five were semi-rural locations made popular due to the lifestyle they offered.last_img read more