10 months agoDONE DEAL: Wolves winger Jordan Graham joins Oxford

first_imgDONE DEAL: Wolves winger Jordan Graham joins Oxfordby Paul Vegas10 months agoSend to a friendShare the loveWolves winger Jordan Graham will join Oxford United on loan in January until the end of the season.Graham, 23, was due to be on loan at Ipswich Town for the entire campaign but that agreement was cut short.The former Aston Villa man spent time on loan at Oxford in 2015 and will return to the League One club when the transfer window opens.”I feel so happy to be back and it’s a pleasure to come back,” Graham said in a video on social media. TagsTransfersLoan MarketAbout the authorPaul VegasShare the loveHave your saylast_img

10 months agoChelsea boss Sarri pleased with matchwinner Kante: He’s improving

first_imgAbout the authorPaul VegasShare the loveHave your say Chelsea boss Sarri pleased with matchwinner Kante: He’s improvingby Paul Vegas10 months agoSend to a friendShare the loveChelsea boss Maurizio Sarri was delighted with matchwinner N’Golo Kante for victory at Crystal Palace.The midfielder struck the only goal of the game.Sarri stated: “He has to think about the defence first of all. Then he is improving, especially in movements without the ball. His movement today was really very good and was done with the right timing.”When we have to play against opponents who are very low, it’s difficult for the striker and wingers to find space. So for us the midfielders’ movement without the ball is very important.”Now we have to work on Loftus-Cheek and on Barkley. Loftus-Cheek especially is a great player with the ball, but he can improve a lot in his movement without the ball.” last_img read more

12 days agoBrighton midfielder Stephens has no doubts about Connolly potential

first_imgAbout the authorPaul VegasShare the loveHave your say Brighton midfielder Stephens has no doubts about Connolly potentialby Paul Vegas12 days agoSend to a friendShare the loveBrighton midfielder Dale Stephens has no doubts about the potential of Aaron Connolly.he 19-year-old grabbed the headlines with a double strike against Tottenham on his first Prem start. Asked whether Connolly has the ability to get under defenders’ skins, Stephens replied: “Yes, he’s got that side to his game and he’s going to need it.“He’s not a big lad, and he has got different abilities to a big centre-forward but he can use what he has got to his advantage.“Being a pain and a pest is what he is good at and that proved good for us (against Tottenham).” last_img

4 days agoNewcastle fullback Jetro Willems: We ran Chelsea close

first_imgAbout the authorPaul VegasShare the loveHave your say Newcastle fullback Jetro Willems: We ran Chelsea closeby Paul Vegas4 days agoSend to a friendShare the loveNewcastle United fullback Jetro Willems has urged teammates to stay calm after their 1-0 loss at Chelsea.The narrow defeat plunged the Magpies back into the relegation zone and piled the pressure back on the team ahead of next weekend’s tough encounter with Wolverhampton Wanderers at St James’ Park.Willems said: “It was close. I think we had the game under control and we were a little bit unlucky.”If it wasn’t for the goal I think we did good defensively – they have a good team and they are difficult players to play against.”Attacking, we could do more.”In the first half, we could have been more dangerous on the counter attack.”We had some chances – sometimes we were unlucky, but sometimes I think we need to just shoot when we are in front of goal.” last_img read more

Ohio State’s Thad Matta Was Pretty Unhappy With The Referees Following His Team’s Loss To Michigan State Last Night

first_imgThad Matta yells at a referee.Thad Matta did a lot of screaming during his team’s game against Michigan State Friday night. Plenty that yelling was directed at his players, who performed quite poorly in a 76-67 loss to the Spartans in the Big Ten Tournament quarterfinal round. But a lot of it was aimed at the officials. Matta, 47, has been coaching in the conference since 2004. He, in a roundabout way, called the officiating during last night’s game the worst he’s ever seen. Matta on the officiating: “I’ve been in this league 11 years and that was amazing.”— Kevin Trahan (@k_trahan) March 14, 2015Matta was mostly unhappy with the amount of physicality the Spartans were getting away with. He believed his players were getting bumped on cuts, hand checked when dribbling and bodied when driving into the lane. Matta says this was one of the most physical games he’s ever seen. My interpretation: “We got hacked to death.”— Jerod Smalley (@JerodNBC4) March 14, 2015To be fair to the refs, there was an even distribution when it comes to the amount of fouls that were called – 20 on Michigan State and 18 on Ohio State. With the win, the Spartans moved on to the semifinal round, where they’ll face No. 2 seed Maryland. The Buckeyes, meanwhile, will find out their NCAA Tournament fate Sunday night. Most projections have Matta’s team seeded on the No. 8/No. 9 line.last_img read more

Mayim Bialik Wants Animal Cosmetic Testing Banned In US

first_imgCalifornia’s Senate this week approved a measure by State Senator Marty Block (SD-39) that urges the U.S to join California, the European Union (EU), and the countries of Norway, India, and Israel in banning animal testing of cosmetic products.Mayim Bialik endorses SJR 22Credit/Copyright: Cruelty Free InternationalBlock’s joint resolution, SJR 22, approved on a bipartisan vote of 31-0, urges the federal government to mandate alternative methods to animal testing when other testing methods are available. It is sponsored by Cruelty Free International and also supported by the American Society for the Prevention of Cruelty to Animals, the Animal Legal Defense Fund, the State Humane Association and others.“Unnecessary cruelty is unforgiveable,” Block said. “Animal testing by the cosmetics industry is usually unnecessary and often unreliable. Where other means of ensuring product safety are available, they should be used.”“Cruel” tests on rabbits, guinea pigs and mice include force-feeding of animals with testing substances or repeated application of substances to an animal’s skin. After the experiments, the animals are then killed. Block and Cruelty Free International argue that more reliable, quicker, and less expensive alternatives are available and should be used. Alternatives include computer modeling and tests on human skin donated from cosmetic surgery or examination of proteins in-vitro (in a test tube).Actress Mayim Bialik – who portrays Amy Farrah Fowler on the hit show “The Big Bang Theory” – is a Cruelty Free International supporter. “I am thrilled to join Senator Marty Block in asking the California Legislature to support SJR 22, the Cruelty Free Cosmetics Resolution.”She added, “For over a decade California has been a leader in supporting the use of modern non-animal tests to ensure cosmetics safety. It’s time that the rest of the nation catches up with California as well as other counties on this issue. I am proud to stand with Senator Block in calling for cruelty free testing.”North America Campaign Manager for Cruelty Free International Monica Engebretson also emphasized that product safety is possible without the use of the older, more inhumane testing. “Our success in ending cosmetics testing on animals in the European Union has proven that it is possible and safe to create cosmetics without animal testing,” Engebretson said.California became the first state to restrict animal testing in 2000. Some countries such as those in the EU have completely banned the importation and sale of animal-tested products. EU sales account for nearly half of the global cosmetics market.SJR 22 also calls on the U.S. Congress to enact legislation that would establish reasonable deadlines for the prohibition on the testing and marketing of products which have been tested on animals.last_img read more

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first_imgShareTweet “People across this island are alive to the constitutional change that is unfolding in front of us. “The Scottish people are about to embark on a new conversation about independence, it is likely that Boris Johnson will soon be the British Prime Minister. “Old political certainties and old majorities are no more. On an island of many political minorities, the only option is to build a broad coalition for change.“Scottish Independence campaigners compiled a 600 page manifesto outlining what health services, schools, the economy and investment would look like in their new Scotland. “They built a vibrant coalition across classes, creeds and backgrounds. “And even then, they fell just short. Irish Nationalism must learn that lesson. “We must now put in the hard yards to persuade our friends and neighbours that their interests are best served in a reconciled and prosperous new Ireland. We must spill our sweat to create that vision.“No one party can shape that vision of a New Ireland. “I have previously proposed the re-establishment of the New Ireland Forum post Brexit to secure a broad investment from all parties. “It remains the best way to produce a blueprint for unity.“Let the conversation that we’re about to have be based on what’s best for people. Let it be a cross-community conversation on a vision for the future that reflects where we are and where we want to be. “That’s the challenge that lies ahead,” added the SDLP leader.Eastwood welcomes recognition of need for Unity plan was last modified: June 7th, 2019 by John2John2 Tags: He said: “I’m glad to hear that Sinn Féin is moving to the position that I have been outlining for some time. “Their initial reaction to my suggestion that calling for a border poll with no plan or idea on how it would be delivered would be madness was entirely negative. “Indeed, they have spent months attacking SDLP members for that view.“It has taken time, as these things often do, but I’m glad that Sinn Féin leaders are now coming to the SDLP position. colum eastwoodEastwood welcomes recognition of need for Unity planFOYLE MLASDLP LEADERSinn FeinUnity Plan SDLP leader Colum EastwoodSDLP Leader Colum Eastwood has welcomed recognition from former Sinn Féin President Gerry Adams that a comprehensive plan is needed for Irish Unity before any referendumThe Foyle MLA said that it has taken parties too long to come to that realisation.last_img read more

Highdose influenza vaccine associated fewer hospitalizations in dialysis patients

first_imgReviewed by Alina Shrourou, B.Sc. (Editor)Oct 24 2018Results from a new study suggest that high-dose influenza vaccine is associated with lower risk for hospitalizations in kidney failure patients on dialysis. The findings appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).High-dose influenza vaccine, which contains fourfold more antigen than the standard dose, is linked with fewer cases of influenza and less severe influenza symptoms in the elderly general population. Whether the high-dose influenza vaccine benefits dialysis patients, whose immune response to vaccination is less robust than healthy patients, is uncertain. To investigate, Dana Miskulin, MD (Tufts Medical Center) and her colleagues compared hospitalizations and deaths during the 2015-16 and 2016-17 influenza seasons by vaccine type (standard trivalent, standard quadrivalent, and high-dose trivalent influenza vaccine) administered to more than 9000 patients in season within a national dialysis organization.Related StoriesNovel vaccine against bee sting allergy successfully testedResearchers identify possible role of polyphosphate in dialysis-related amyloidosis$3.1 million NIH funding awarded to develop universal flu vaccineReceiving high-dose vs. standard dose influenza vaccine in 2016-17 was associated with lower rates of hospitalization in dialysis patients, although this association was not seen in 2015-16. There were no differences in rates of death between patients receiving the high-dose vs. standard dose influenza vaccine during either influenza season.”We found that the administration of the high-dose influenza vaccine was associated with 8% fewer first hospitalizations than the standard dose vaccine in 2016-17. In 2015-16 there was no difference by vaccine type although statistical power was limited, with only 8% of patients receiving high dose that year, compared with 61% in 2016-17,” said Dr. Miskulin.Dr. Miskulin noted that the 2016-17 season results are consistent with lower hospitalizations with high-dose as compared with standard dose seen in the elderly general population. Adverse events were not collected in this study, but large clinical trials in the general population suggest that the high-dose vaccine is not associated with more adverse effects. “While these results should not be considered definitive, because vaccine type was not randomized, they suggest that there may be a reduction in influenza related morbidity in dialysis patients with use of the high-dose vs. standard dose vaccine,” said Dr. Miskulin.Studies of other strategies to increase influenza vaccine effectiveness in dialysis patients and other immunocompromised populations, including the use of adjuvants and booster doses, could also be beneficial, according to an accompanying editorial by Megan Lindley, MPH and David Kim, MD (Centers for Disease Control and Prevention). “Even in the absence of increased vaccine effectiveness, improvements in influenza vaccination coverage among medically vulnerable populations such as dialysis patients could increase protection against influenza,” they wrote. “In groups where the burden of influenza disease and its complications are disproportionately felt, small improvements in vaccine effectiveness and vaccination coverage may have large impacts.” Source:https://www.asn-online.org/last_img read more

Study Using steroids during cardic bypass surgery did not reduce acute kidney

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 4 2019Using steroids during cardiopulmonary bypass surgery did not reduce the risk of acute kidney injury in people at increased risk of death, according to a study conducted in 18 countries published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.181644.The multisite randomized controlled trial, funded by the Canadian Institutes of Health Research, included patients in Canada, China, India, United States, Colombia, Australia, Italy, Iran, Czech Republic, Greece, Spain, Brazil, Austria, Belgium, Hong Kong, Argentina, Chile and Ireland, which broadens the reach of the study’s findings.Related StoriesChronic kidney disease patients are excluded from clinical trialsResearchers investigate whether hypertension poses health risk to older kidney donorsTen-fold rise in tongue-tie surgery for newborns ‘without any real strong data’About one-fifth of the millions of bypass surgeries performed around the world each year result in acute kidney injury, which in its most severe forms greatly increases the chance of death and the need for life-sustaining dialysis treatments. Bypass surgery can trigger widespread inflammation, which is thought to be a key culprit in the development of kidney injury. Prior studies suggested that steroids might help reduce inflammation and acute kidney injury.”Administering steroids to prevent inflammation during surgery did not reduce the risk of acute kidney injury in people at moderate or high risk of adverse effects,” says author Dr. Amit Garg, a scientist at Lawson Health Research Institute and professor at Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.The study included 7286 patients, of whom about half (3647) were randomized to receive steroids and the remaining 3639 to placebo. The rate of acute kidney injury was similar in both groups.”Given the broad range of countries and populations represented in the study, these findings further support a shift away from using steroids as an effective method of preventing the complications from inflammation during bypass surgery,” states Dr. Garg. Source:http://www.cmaj.ca/last_img read more

Brussels backs efforts to save EU digital tax proposal

first_img Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. France, backed by EU-presidency holder Austria, has been urging European Union partners to impose a new tax to ensure that global tech platforms like Facebook and Google pay their fair share Citation: Brussels backs efforts to save EU digital tax proposal (2018, November 7) retrieved 17 July 2019 from https://phys.org/news/2018-11-brussels-efforts-eu-digital-tax.html France races to save EU digital tax proposalcenter_img © 2018 AFP The European Commission on Wednesday urged backers of an EU-wide tax on high-tech giants to keep pushing the proposal, which has stalled due to opposition from Ireland and Nordic countries. France, backed by EU-presidency holder Austria, has been urging European Union partners to impose a new tax to ensure that global tech platforms like Facebook and Google pay their fair share.Paris argues the measure would be a vote-winning accomplishment for mainstream EU politicians before the European Parliament elections next May, in which anti-Brussels populists could do well.”When it comes to taxation you need to push to make it happen. For me personally it’s a very important proposal,” European Competition Commissioner Margrethe Vestager told a news conference at the Web Summit, a annual teach gathering, in Lisbon.”I do hope that the Austrians will keep the pressure to make this happen,” she said.Digital firms pay on average just 9 percent in “effective taxation”, compared to an average of 23 percent for other firms, Europe’s antitrust chief said.”When in a technological revolution, if it’s not to be a wild west, you must be willing to regulate it,” said Vestager.The French government had wanted a tax proposal by the end of the year but on Tuesday Paris agreed to put off its implementation until 2020 to give more time to get opponents on side.European tax rules require unanimous backing by all European Union members.Ireland, which hosts the European headquarters of several US tech giants, leads a small group of otherwise mostly Nordic countries that argue the tax will also punish European companies and stoke Washington’s anger.last_img read more

A Common Cold Virus Wiped Away Bladder Cancer in One Patient

first_imgA simple cold virus could wipe out tumors in a form of bladder cancer, a small new study suggests. Though the idea of using viruses to fight cancer isn’t new, this is the first time a cold virus effectively treated an early-stage form of bladder cancer. In one patient, it eliminated a cancerous tumor, the group reported July 4 in the journal Clinical Cancer Research. A group of researchers conducted an early-stage clinical trial in which they infected 15 bladder cancer patients with coxsackievirus A21, which is one of the viruses that cause the common cold. Coxsackievirus is not a genetically modified virus; it’s “something that occurs in nature,” said senior author Hardev Pandha, a professor of medical oncology at the University of Surrey in England. [Exercise May Reduce the Risk of These 13 Cancers]These Sharks Were Too Busy to Notice a Bigger Predator Watching ThemThe unexpected twist at the end of this feeding frenzy delighted scientists.Credit: NOAA Office of Ocean Exploration and Research, Windows to the Deep 2019Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Headbutting Tiny Worms Are Really, Really Loud00:35关闭选项Automated Captions – en-US facebook twitter 发邮件 reddit 链接https://www.livescience.com/65908-cold-virus-might-treat-bladder-cancer.html?jwsource=cl已复制直播00:0002:2802:28  The researchers gave the patients the virus through catheters that the patients already had inserted for other treatments. They left the virus-filled catheter in for an hour to pump the fluids into the bladder and repeated this treatment. Then, the patients underwent surgery to remove what was left of their bladder tumors. In one patient, the virus completely destroyed the tumor. In all of the other patients, the researchers found evidence that the virus had damaged the tumors and had spurred the immune system to send an army of immune cells to the tumors. None of the patients had any significant side effects, Pandha said. Researchers thought this method would work because the outer membranes of cancerous bladder cells contain a gateway for the coxsackievirus: a molecule called ICAM-1. Because healthy cells don’t carry this molecule, the coxsackievirus doesn’t attack them. Once the virus gets into the cell, it hijacks the cell’s machinery and ends up killing it. Even more cancer cells die when the immune cells are recruited. ICAM-1 is also expressed by other cancer cells, and coxsackievirus has, in fact been previously shown to be effective in treating very advanced bladder cancer and other cancers, such as melanoma, Pandha said. Even so, this is still an early-stage trial, and there’s still a long way to go before the method can be used in treatment, Pandha said. “This would be the foundation for much larger studies where we’d build on this,” he said. Newer studies will try to make the treatment more effective and stop the cancer from coming back, he added. Unfortunately, just getting a common cold won’t treat the cancer on its own. Pandha’s team gave a much higher dose of the virus than you would get if someone coughed on you and you got sick, for example. Interestingly, the patients who were given the virus through the catheter did not get cold symptoms. “I agree that [such viruses are] good therapeutic target[s]” for certain types of cancers, like bladder cancer, said Grant McFadden, director of the Biodesign Center for Immunotherapy, Vaccines and Virotherapy at Arizona State University, who was not a part of the study. But he noted that many studies have looked at whether viruses can target cancer cells. In fact, a host of viruses have been studied for attacking bladder cancer, specifically. It’s likely that many viruses will work well to treat bladder cancer and at least some tumor-destroying viruses “will get approved for use in humans,” McFadden told Live Science. “But this paper isn’t really new or innovative.” In fact, the idea of using viruses to treat cancer goes back nearly 100 years, Pandha said, but only in the past decade or so has it gained momentum. Editor’s note: This article was updated. Only a couple of the authors (not Pandha) are employed by Viralytics, a Merck-owned biotech company that is developing viral-based cancer treatments. Colorful But Deadly: Images of Brain Cancer 7 Side Effects of Cancer Treatment, and How to Cope with Them 7 Odd Things That Raise Your Risk of Cancer (and 1 That Doesn’t) Originally published on Live Science.by Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeBrilliant Future10 Worst Paying College MajorsBrilliant FutureUndoThe SideHairstyles That Make You Look Younger Than EverThe SideUndoMy Daily DiscoveryHow To Keep Your Photos And Videos SafeMy Daily DiscoveryUndoDugiFeed11 Best Foods for Diabetes ControlDugiFeedUndoYour Health7 Natural Pain Relief TechniquesYour HealthUndoeasyrecipes20 Toughest Restaurants Worldwide To Get A Reservation (But Worth The Wait)easyrecipesUndolast_img read more

UK working with TN govt on electric vehicles

first_imgSHARE The picture is just for representational purpose COMMENT British Deputy High Commissioner, Jeremy Pilmore-Bedford, said that they are working with the Tamil Nadu government to support the Electric Vehicle (EV) plan for the state. Speaking at the Chennai TechFest, an event organised by the British Deputy High Commission and TiE Chennai, he said the Transport Minister and Secretary from Tamil Nadu visited the Transport of London and few of the EV companies in the UK this September.“We are planning to bring a delegation of UK corporate officials with expertise in EVs to Chennai in January,” Pilmore-Bedford added. The Deputy High Commissioner also commented that the UK is undergoing a start-up revolution, similar to India. This has resulted in the UK having one in every three tech unicorns from Europe. “A staggering 31 per cent of Indian investments in the UK are in the technology sector and that is responsible for 30,000 jobs in UK, “ Pilmore-Bedford said.Dr. Santosh Babu, Secretary to Government, Information Technology Department, Tamil Nadu, listed out various business-friendly measures taken by the state government. Speaking on the occasion, he said the ecosystem for start-ups looks bright in the state. The Chennai event is part of a series of events organised across different cities as a preview to the ‘India-UK FutureTech Festival’ to be held in New Delhi on December 12. Future Tech Festival (FTF) is a thought-leadership summit that brings together leaders, policy-makers, venture capitalists and entrepreneurs from both the countries to explore investment opportunities in the field of technology and to mentor emerging entrepreneurs and start-up companies. The festival was initiated by Prime Minister Narendra Modi and UK Prime Minister Theresa May during the former’s visit to the country in April this year. November 24, 2018 Published on electric vehicles COMMENTS SHARE SHARE EMAILlast_img read more